Sam Cheng

Sam Cheng, M.D.

Clinical Associate Professor

Business Phone: (352) 273-9350

About Sam Cheng

Sam Cheng, MD, MSc, PhD, earned his medical degree and master’s degree in clinical investigation from Tongji Medical University in China, and then trained in Molecular Biology and Genetics while being a World Health Organization fellow at the Great Ormond Street Hospital/Child Health Institute in London. Subsequently, he completed his doctoral degree in Ion Transport Physiology and Biochemistry at Karolinska Institute in Stockholm, Sweden. Dr. Cheng completed two pediatric residencies – one at Tongji Hospital in Wuhan, China and the other at SUNY Downstate Medical Center in Brooklyn, New York. As a postdoctoral fellow at Yale University in Connecticut, Dr. Cheng expanded his training in fluids, electrolytes and nutrition and calciumĀ¬sensing receptor physiology and pathology, in relation to diarrhea, inflammatory bowel disease, and neuro-gastrointestinal diseases in children. Dr. Cheng is board-certified in pediatrics and pediatric gastroenterology and is an Associate Professor for the Department of Pediatrics at the University of Florida College of Medicine. His work and research has resulted in multiple awards, grants and patents, and published articles in the Journal of Clinical Investigation, Gastroenterology, the Proceedings of the National Academy of Sciences, and the American Journal of Physiology. His current work builds on his prior work and previous training in combination with his current interests as a GI physiologist and pediatric gastroenterologist. He is particularly interested in pediatric nutrition, inflammatory bowel disease, short bowel syndrome, irritable bowel syndrome and other diarrheal disorders in children. Also, Dr. Cheng helps running UF Pediatric Short Bowel clinic and UF Pediatric Anorectal Manometry program.

Board Certifications

  • Pediatric Gastroemterology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Clinical Profile

  • Pediatrics
  • Pediatric Gastroenterology

Research Profile

Areas of Interest
  • Calcium-Sensing Receptor and Nutrient-Sensing
  • Diarrheal Disease
  • Electrophysiology
  • Fluid, Electrolyte and Nutrition
  • Gastrointestinal Physiology
  • Short bowel syndrome


Gastric electrical stimulation: An emerging therapy for children with intractable gastroparesis.
World journal of gastroenterology. 25(48):6880-6889 [DOI] 10.3748/wjg.v25.i48.6880. [PMID] 31908392.
Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-26171-4. [PMID] 29777154.
Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons.
Life sciences. 194:49-58 [DOI] 10.1016/j.lfs.2017.12.019. [PMID] 29247746.
Extracellular Calcium Dictates Onset, Severity, and Recovery of Diarrhea in a Child with Immune-Mediated Enteropathy.
Frontiers in pediatrics. 6 [DOI] 10.3389/fped.2018.00007. [PMID] 29435439.
Inability to reduce morbidity of diarrhea by ORS: can we design a better therapy?
Pediatric research. 83(3):559-563 [DOI] 10.1038/pr.2017.295. [PMID] 29168980.
Bumetanide increases Cl–dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0171045. [PMID] 28152000.
Calcium-sensing receptor: A new target for therapy of diarrhea.
World journal of gastroenterology. 22(9):2711-24 [DOI] 10.3748/wjg.v22.i9.2711. [PMID] 26973410.
Corrigendum: The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Frontiers in physiology. 7 [DOI] 10.3389/fphys.2016.00315. [PMID] 27461573.
The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Frontiers in physiology. 7 [DOI] 10.3389/fphys.2016.00245. [PMID] 27458380.
The role of the calcium-sensing receptor in gastrointestinal inflammation.
Seminars in cell & developmental biology. 49:44-51 [DOI] 10.1016/j.semcdb.2015.10.040. [PMID] 26709005.
Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon.
American journal of physiology. Gastrointestinal and liver physiology. 308(10):G874-83 [DOI] 10.1152/ajpgi.00341.2014. [PMID] 25792563.
Calcium-Sensing Receptor in Ens: a Mechanism To Inhibit Enteric Nerve Activity and Reduce Diarrhea
Neurogastroenterology and Motility. 26(1, SI)
Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection.
PloS one. 9(6) [DOI] 10.1371/journal.pone.0100532. [PMID] 24945934.
Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.
FEBS letters. 588(22):4158-66 [DOI] 10.1016/j.febslet.2014.05.007. [PMID] 24842610.
Calcium ameliorates diarrhea in immunocompromised children.
Journal of pediatric gastroenterology and nutrition. 56(6):641-4 [DOI] 10.1097/MPG.0b013e3182868946. [PMID] 23343935.
Celiac disease in a child with ulcerative colitis: a possible genetic association.
Journal of clinical gastroenterology. 47(2):127-9 [DOI] 10.1097/MCG.0b013e318250e468. [PMID] 23314669.
Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system.
American journal of physiology. Gastrointestinal and liver physiology. 303(1):G60-70 [DOI] 10.1152/ajpgi.00425.2011. [PMID] 22517767.
Jejunal adaptation in a prepubertal boy after total ileal resection and jejunostomy placement: a four-year follow-up.
Journal of clinical gastroenterology. 45(10):846-9 [DOI] 10.1097/MCG.0b013e318214b2d9. [PMID] 21552141.
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America. 104(10):4020-4 [PMID] 17360470.
View on: PubMed
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.
Proceedings of the National Academy of Sciences of the United States of America. 103(25):9390-7 [PMID] 16760252.
View on: PubMed
The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands.
American journal of physiology. Gastrointestinal and liver physiology. 289(6):G1084-90 [PMID] 16109841.
View on: PubMed
Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor.
Gastroenterology. 126(1):148-58 [PMID] 14699496.
View on: PubMed
Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract.
Cell calcium. 35(3):239-47 [PMID] 15200147.
View on: PubMed
Mechanisms of Na+-K+-ATPase phosphorylation by PKC in the medullary thick ascending limb of Henle in the rat.
Pflugers Archiv : European journal of physiology. 447(1):87-96 [PMID] 12905033.
View on: PubMed
Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion.
American journal of physiology. Gastrointestinal and liver physiology. 283(1):G240-50 [PMID] 12065312.
View on: PubMed
Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase.
Acta physiologica Scandinavica. 175(2):165-71 [PMID] 12028137.
View on: PubMed
Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats.
Diabetes. 49(8):1381-9 [PMID] 10923641.
View on: PubMed
[Ca2+]i determines the effects of protein kinases A and C on activity of rat renal Na+,K+-ATPase.
The Journal of physiology. 518(Pt 1):37-46 [PMID] 10373687.
View on: PubMed
Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase.
The American journal of physiology. 275(6):F863-9 [DOI] 10.1152/ajprenal.1998.275.6.F863. [PMID] 9843902.
Forskolin-induced down-regulation of Na+,K(+)-ATPase activity is not associated with internalization of the enzyme.
Acta physiologica Scandinavica. 164(1):39-46 [PMID] 9777023.
View on: PubMed
20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase.
The Journal of clinical investigation. 99(6):1224-30 [PMID] 9077530.
View on: PubMed
PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone.
The American journal of physiology. 273(3 Pt 1):C893-901 [PMID] 9316410.
View on: PubMed
Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA.
The American journal of physiology. 273(6):C1981-6 [DOI] 10.1152/ajpcell.1997.273.6.C1981. [PMID] 9435504.
Cellular mechanisms for bi-directional regulation of tubular sodium reabsorption.
Kidney international. 49(6):1743-7 [PMID] 8743489.
View on: PubMed
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.
The Journal of biological chemistry. 269(12):9368-73 [PMID] 7510709.
View on: PubMed
Duplication of chromosome 15 in the region 15q11-13 in a patient with developmental delay and ataxia with similarities to Angelman syndrome.
Journal of medical genetics. 30(6):529-31 [PMID] 8326502.
View on: PubMed
Molecular mechanisms in Angelman syndrome: a survey of 93 patients.
Journal of medical genetics. 30(11):895-902 [PMID] 7905534.
View on: PubMed
Angelman syndrome with a chromosomal inversion 15 inv(p11q13) accompanied by a deletion in 15q11q13.
Journal of medical genetics. 29(12):921-4 [PMID] 1362225.
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Further evidence for dominant inheritance at the chromosome 15q11-13 locus in familial Angelman syndrome.
American journal of medical genetics. 44(2):256-60 [PMID] 1360768.
View on: PubMed
Study on immunopathogenesis of minimal change nephropathy. Effects of mitogens activated lymphocytes on glomerular polyanions in vitro.
Chinese medical journal. 102(7):524-8 [PMID] 2517068.
View on: PubMed
[Effects of mitogen-activated lymphocytes on glomerular polyanion (GPA) in rats].
Zhonghua yi xue za zhi. 68(12):691-2, 48 [PMID] 3248251.
View on: PubMed


Apr 2017 – Mar 2019
Development of CaSR nutrient therapy for childhood diarrhea
Role: Principal Investigator
Apr 2014 – Mar 2020
Calcium Receptor Action in Childhood Diarrhea
Role: Principal Investigator


Issued June 2018
CaSR Nutrient-Based Therapies for Diarrhea
Published June 2018
Materials and Methods for Prevention and Treatment of Diarrhea and Inflammationin the Gastrointestinal Tract
Published November 2017
Correction of Cystic Fibrosis Bicarbonate Secretion Defect with CaSR Agonists


Fellowship – Pediatric Gastroenterology
2012 · Yale University
Residency – Pediatrics
2009 · Suny Downstate Medical Center
Internship – Pediatrics
2007 · Suny Downstate Medical Center
Fellowship – Pediatrics
1992 · The Great Ormond Street Hospitap
Residency – Pediatrics
1989 · Tongji Hospital

Contact Details

(352) 273-9350