Sam Cheng

Sam Cheng, M.D.

Clinical Associate Professor

Department: MD-PEDS-GASTROENTEROLOGY
Business Phone: (352) 273-9350

About Sam Cheng

Sam Cheng, MD, MSc, PhD, earned his medical degree and master’s degree in clinical investigation from Tongji Medical University in China, and then trained in Molecular Biology and Genetics while being a World Health Organization fellow at the Great Ormond Street Hospital/Child Health Institute in London. Subsequently, he completed his doctoral degree in Ion Transport Physiology and Biochemistry at Karolinska Institute in Stockholm, Sweden. Dr. Cheng completed two pediatric residencies – one at Tongji Hospital in Wuhan, China and the other at SUNY Downstate Medical Center in Brooklyn, New York. As a postdoctoral fellow at Yale University in Connecticut, Dr. Cheng expanded his training in fluids, electrolytes and nutrition and calciumĀ¬sensing receptor physiology and pathology, in relation to diarrhea, inflammatory bowel disease, and neuro-gastrointestinal diseases in children. Dr. Cheng is board-certified in pediatrics and pediatric gastroenterology and is an Associate Professor for the Department of Pediatrics at the University of Florida College of Medicine. His work and research has resulted in multiple awards, grants and patents, and published articles in the Journal of Clinical Investigation, Gastroenterology, the Proceedings of the National Academy of Sciences, and the American Journal of Physiology. His current work builds on his prior work and previous training in combination with his current interests as a GI physiologist and pediatric gastroenterologist. He is particularly interested in pediatric nutrition, inflammatory bowel disease, short bowel syndrome, irritable bowel syndrome and other diarrheal disorders in children. Also, Dr. Cheng helps running UF Pediatric Short Bowel clinic and UF Pediatric Anorectal Manometry program.

Board Certifications

  • Pediatric Gastroemterology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Pediatric Gastroenterology

Research Profile

Areas of Interest
  • Calcium-Sensing Receptor and Nutrient-Sensing
  • Diarrheal Disease
  • Electrophysiology
  • Fluid, Electrolyte and Nutrition
  • Gastrointestinal Physiology
  • Short bowel syndrome

Publications

2019
Gastric electrical stimulation: An emerging therapy for children with intractable gastroparesis.
World journal of gastroenterology. 25(48):6880-6889 [DOI] 10.3748/wjg.v25.i48.6880. [PMID] 31908392.
2018
Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-26171-4. [PMID] 29777154.
2018
Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons.
Life sciences. 194:49-58 [DOI] 10.1016/j.lfs.2017.12.019. [PMID] 29247746.
2018
Extracellular Calcium Dictates Onset, Severity, and Recovery of Diarrhea in a Child with Immune-Mediated Enteropathy.
Frontiers in pediatrics. 6 [DOI] 10.3389/fped.2018.00007. [PMID] 29435439.
2018
Inability to reduce morbidity of diarrhea by ORS: can we design a better therapy?
Pediatric research. 83(3):559-563 [DOI] 10.1038/pr.2017.295. [PMID] 29168980.
2017
Bumetanide increases Cl–dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0171045. [PMID] 28152000.
2016
Calcium-sensing receptor: A new target for therapy of diarrhea.
World journal of gastroenterology. 22(9):2711-24 [DOI] 10.3748/wjg.v22.i9.2711. [PMID] 26973410.
2016
Corrigendum: The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Frontiers in physiology. 7 [DOI] 10.3389/fphys.2016.00315. [PMID] 27461573.
2016
The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.
Frontiers in physiology. 7 [DOI] 10.3389/fphys.2016.00245. [PMID] 27458380.
2016
The role of the calcium-sensing receptor in gastrointestinal inflammation.
Seminars in cell & developmental biology. 49:44-51 [DOI] 10.1016/j.semcdb.2015.10.040. [PMID] 26709005.
2015
Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon.
American journal of physiology. Gastrointestinal and liver physiology. 308(10):G874-83 [DOI] 10.1152/ajpgi.00341.2014. [PMID] 25792563.
2014
Calcium-Sensing Receptor in Ens: a Mechanism To Inhibit Enteric Nerve Activity and Reduce Diarrhea
Neurogastroenterology and Motility. 26(1, SI)
2014
Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection.
PloS one. 9(6) [DOI] 10.1371/journal.pone.0100532. [PMID] 24945934.
2014
Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.
FEBS letters. 588(22):4158-66 [DOI] 10.1016/j.febslet.2014.05.007. [PMID] 24842610.
2013
Calcium ameliorates diarrhea in immunocompromised children.
Journal of pediatric gastroenterology and nutrition. 56(6):641-4 [DOI] 10.1097/MPG.0b013e3182868946. [PMID] 23343935.
2013
Celiac disease in a child with ulcerative colitis: a possible genetic association.
Journal of clinical gastroenterology. 47(2):127-9 [DOI] 10.1097/MCG.0b013e318250e468. [PMID] 23314669.
2012
Calcium-Sensing Receptor Inhibits Secretagogue-Induced Electrolyte Secretion By Intestine Via the Enteric Nervous System
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303(1):G60-G70 [DOI] 10.1152/ajpgi.00425.2011. [PMID] 22517767.
2011
Jejunal adaptation in a prepubertal boy after total ileal resection and jejunostomy placement: a four-year follow-up.
Journal of clinical gastroenterology. 45(10):846-9 [DOI] 10.1097/MCG.0b013e318214b2d9. [PMID] 21552141.
2007
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America. 104(10):4020-4 [PMID] 17360470.
View on: PubMed
2006
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.
Proceedings of the National Academy of Sciences of the United States of America. 103(25):9390-7 [PMID] 16760252.
View on: PubMed
2005
The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands.
American journal of physiology. Gastrointestinal and liver physiology. 289(6):G1084-90 [PMID] 16109841.
View on: PubMed
2004
Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor.
Gastroenterology. 126(1):148-58 [PMID] 14699496.
View on: PubMed
2004
Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract.
Cell calcium. 35(3):239-47 [PMID] 15200147.
View on: PubMed
2003
Mechanisms of Na+-K+-ATPase phosphorylation by PKC in the medullary thick ascending limb of Henle in the rat.
Pflugers Archiv : European journal of physiology. 447(1):87-96 [PMID] 12905033.
View on: PubMed
2002
Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion.
American journal of physiology. Gastrointestinal and liver physiology. 283(1):G240-50 [PMID] 12065312.
View on: PubMed
2002
Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase.
Acta physiologica Scandinavica. 175(2):165-71 [PMID] 12028137.
View on: PubMed
2000
Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats.
Diabetes. 49(8):1381-9 [PMID] 10923641.
View on: PubMed
1999
[Ca2+]i determines the effects of protein kinases A and C on activity of rat renal Na+,K+-ATPase.
The Journal of physiology. 518(Pt 1):37-46 [PMID] 10373687.
View on: PubMed
1998
Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase.
The American journal of physiology. 275(6):F863-9 [DOI] 10.1152/ajprenal.1998.275.6.F863. [PMID] 9843902.
1998
Forskolin-induced down-regulation of Na+,K(+)-ATPase activity is not associated with internalization of the enzyme.
Acta physiologica Scandinavica. 164(1):39-46 [PMID] 9777023.
View on: PubMed
1997
20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase.
The Journal of clinical investigation. 99(6):1224-30 [PMID] 9077530.
View on: PubMed
1997
PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone.
The American journal of physiology. 273(3 Pt 1):C893-901 [PMID] 9316410.
View on: PubMed
1997
Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA.
The American journal of physiology. 273(6):C1981-6 [DOI] 10.1152/ajpcell.1997.273.6.C1981. [PMID] 9435504.
1996
Cellular mechanisms for bi-directional regulation of tubular sodium reabsorption.
Kidney international. 49(6):1743-7 [PMID] 8743489.
View on: PubMed
1994
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.
The Journal of biological chemistry. 269(12):9368-73 [PMID] 7510709.
View on: PubMed
1993
Duplication of chromosome 15 in the region 15q11-13 in a patient with developmental delay and ataxia with similarities to Angelman syndrome.
Journal of medical genetics. 30(6):529-31 [PMID] 8326502.
View on: PubMed
1993
Molecular mechanisms in Angelman syndrome: a survey of 93 patients.
Journal of medical genetics. 30(11):895-902 [PMID] 7905534.
View on: PubMed
1992
Angelman syndrome with a chromosomal inversion 15 inv(p11q13) accompanied by a deletion in 15q11q13.
Journal of medical genetics. 29(12):921-4 [PMID] 1362225.
View on: PubMed
1992
Further evidence for dominant inheritance at the chromosome 15q11-13 locus in familial Angelman syndrome.
American journal of medical genetics. 44(2):256-60 [PMID] 1360768.
View on: PubMed
1989
Study on immunopathogenesis of minimal change nephropathy. Effects of mitogens activated lymphocytes on glomerular polyanions in vitro.
Chinese medical journal. 102(7):524-8 [PMID] 2517068.
View on: PubMed
1988
[Effects of mitogen-activated lymphocytes on glomerular polyanion (GPA) in rats].
Zhonghua yi xue za zhi. 68(12):691-2, 48 [PMID] 3248251.
View on: PubMed

Grants

Apr 2017 – Mar 2019
Development of CaSR nutrient therapy for childhood diarrhea
Role: Principal Investigator
Funding: MEDOSOME BIOTEC via NATL INST OF HLTH NICHD
Apr 2014 – Mar 2020
Calcium Receptor Action in Childhood Diarrhea
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD

Patents

Issued June 2018
CaSR Nutrient-Based Therapies for Diarrhea
#9,987,306
Published June 2018
Materials and Methods for Prevention and Treatment of Diarrhea and Inflammationin the Gastrointestinal Tract
#US-2018-0271903-A1
Published November 2017
Correction of Cystic Fibrosis Bicarbonate Secretion Defect with CaSR Agonists
#2018053826

Education

Fellowship – Pediatric Gastroenterology
2012 · Yale University
Residency – Pediatrics
2009 · Suny Downstate Medical Center
Internship – Pediatrics
2007 · Suny Downstate Medical Center
Fellowship – Pediatrics
1992 · The Great Ormond Street Hospitap
Residency – Pediatrics
1989 · Tongji Hospital

Contact Details

Phones:
Business:
(352) 273-9350